JH295 hydrate |
| Catalog No.GC60959 |
El hidrato de JH295 es un inhibidor de la cinasa 2 (Nek2) relacionado con NIMA potente, irreversible y selectivo con una IC50 de 770 nM. El hidrato JH295 inhibe Nek2 celular a través de la alquilaciÓn de Cys22. El hidrato de JH295 es inactivo frente a las quinasas mitÓticas, Cdk1, Aurora B o Plk1, y no perturba el ensamblaje del huso bipolar ni el punto de control del ensamblaje del huso.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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JH295 hydrate is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 770 nM. JH295 hydrate inhibits cellular Nek2 via alkylation of Cys22. JH295 hydrate is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint[1].
JH295 (Compound 16; 0.08-20 μM; 45 minutes; RPMI7951 cells) treatment inhibits WT Nek2 in cells with an IC50 of ~1.3 μM, whereas it has little effect on the C22V mutant[1]. Western Blot Analysis[1] Cell Line: RPMI7951 cells
[1]. Jeffrey C Henise, et al. Irreversible Nek2 kinase inhibitors with cellular activity. J Med Chem. 2011 Jun 23;54(12):4133-46.
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