Pluripotin (Synonyms: SC1) |
| Catalog No.GC17407 |
Pluripotin es un inhibidor dual de ERK1 y RasGAP con KD de 98 nM y 212 nM, respectivamente. Pluripotin también inhibe RSK1, RSK2, RSK3 y RSK4 con IC50 de 0,5, 2,5, 3,3 y 10,0 μM, respectivamente.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 839707-37-8
Sample solution is provided at 25 µL, 10mM.
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Pluripotin is a dual inhibitor of ERK1 and RasGAP with KDs of 98 nM and 212 nM, respectively. Pluripotin also inhibits RSK1, RSK2, RSK3, and RSK4 with IC50s of 0.5, 2.5, 3.3, and 10.0 µM, respectively.
Pluripotin (SC-1) inhibits Abl1, p70S6K, PLK2, RSK1, RSK2, RSK3, RSK4 with IC50s of 0.005, 1.4, 2.2, 0.5, 2.5, 3.3, 10.0 µM,respectively. Pluripotin (SC-1) decreases cell growth for 7 colon tumor cell lines. After a five day exposure to 0.1 µM SC-1, the seven colon tumor lines are evaluated for changes in cell number and viability. There is a statistically significant decrease in cell number but >95% viability[2].
References:
[1]. Chen S, et al. Self-renewal of embryonic stem cells by a small molecule. Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17266-71.
[2]. Mertins SD, et al. A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept. PLoS One. 2013;8(2):e57099.
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