Caspase

Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).

Products for Caspase

Cat.No. Nombre del producto Información
GC45175 YVAD-CHO (trifluoroacetate salt)

H-Tyr-Val-Ala-Asp-CHO
YVAD-CHO is an inhibitor of caspase-1/interleukin-1β converting enzyme (ICE) and a non-acetylated form of Ac-YVAD-CHO.
GC12223 Z-Asp-CH2-DCB

Z-Asp-2,6-Dichlorobenzoyloxymethyl Ketone
Z-Asp-CH2-DCB es un inhibidor irreversible de la caspasa de amplio espectro.
GC66403 Z-DEVD-AMC Z-DEVD-AMC es un sustrato de caspasa-3 selectivo que se puede medir mediante espectrometrÍa de fluorescencia. AMC se puede utilizar como estÁndar de referencia de fluorescencia para sustratos enzimÁticos basados en AMC, incluidos los sustratos de caspasa basados en AMC.
GC45178 Z-DEVD-CMK (trifluoroacetate salt)

Z-Asp-Glu-Val-Asp-CMK

Z-DEVD-CMK is a protease inhibitor.
GC12287 Z-DEVD-FMK Z-DEVD-FMK is a specific irreversible cysteine-aspartic protease 3 (caspase-3) inhibitor with an IC₅₀ of 18μM.
GC16744 Z-DQMD-FMK

Z-DQMD-FMK,Benzyloxycarbonyl-Asp(OMe)-Gln-Met-?Asp(OMe)-fluoromethylketone
Caspase-3 inhibitor,cell-permeable
GC15066 Z-FA-FMK

ZPheAlaFluoromethyl Ketone
An inhibitor of cysteine proteases, including cathepsin B
GC12407 Z-IETD-FMK

Benzyloxycarbonyl-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethylketone, Z-Ile-Glu(OMe)-Thr-Asp(OMe)-FMK
Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) es un inhibidor selectivo y permeable a las células de la caspasa-8.
GC16990 Z-LEHD-FMK Z-LEHD-FMK es un inhibidor selectivo e irreversible de la caspasa-9, protege contra la lesiÓn por reperfusiÓn letal y atenÚa la apoptosis.
GC26092 Z-LEHD-FMK TFA

Caspase-9 Inhibitor
Z-LEHD-FMK TFA (Caspase-9 Inhibitor) is a cell-permeable, competitive and irreversible inhibitor of enzyme caspase-9, which helps in cell survival.
GC72985 Z-LEVD-FMK Z-LEVD-FMK es un inhibide la caspasa-4 permeable a las células.
GC40125 Z-VA-DL-D(OMe)-FMK (trifluoroacetate salt)

Caspase-1 Inhibitor V, Z-VAD-FMK, Z-VAD(OMe)-FMK, Z-Val-Ala-DL-Asp(OMe)-Fluoromethyl Ketone
Z-VA-DL-D(OMe)-FMK (Z-VAD-FMK) is a pan-caspase inhibitor.
GC45189 Z-VAD(OH)-FMK

Z-Val-Ala-Asp-(OH)-Fluoromethyl Ketone
Z-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases.
GC12861 Z-VAD-FMK

Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone,Z-Val-Ala-Asp(OMe)-FMK

Z-VAD-FMK (Z-Val-Ala-Asp(OMe)-FMK) es un inhibidor pan-caspasa irreversible y permeable a la célula. Z-VAD-FMK es un inhibidor de la hidrolasa carboxi-terminal de ubiquitina L1 (UCHL1). Z-VAD-FMK modifica irreversiblemente UCHL1 al dirigirse al sitio activo de UCHL1.
GC11218 Z-VDVAD-FMK

Z-VDVAD-fluoromethylketone, Caspase-2 Inhibitor (fluoromethylketone),Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-FMK
GC13413 Z-VEID-FMK

Caspase-6 inhibitor (fluoromethylketone),Benzyloxycarbonyl-Val-Glu(OMe)-Ile-?Asp(OMe)-fluoromethylketone
GC12190 Z-WEHD-FMK
GC45193 Z-YVAD-CMK (trifluoroacetate salt)

Benxyloxycarbonyl-Tyr-Val-Ala-Asp-Chloromethylketone, Caspase-1 Inhibitor IV

Z-YVAD-CMK is an inhibitor of caspase-1 and caspase-3.
GC14188 Z-YVAD-FMK Z-YVAD-FMK es un inhibidor de caspasa-1 y -4 permeable a las células con actividades antiinflamatorias y antitumorales.
GC37974 ZYZ-488 ZYZ-488 es un inhibidor competitivo del factor 1 activador de la proteasa apoptÓtica (Apaf-1). ZYZ-488 inhibe la activaciÓn de la proteÍna de uniÓn procaspasa-9 y procaspasa-3.