RAD51 Inhibitor B02 (Synonyms: B02) |
Catalog No.GC19306 |
RAD51 Inhibitor B02 (B02) es un inhibidor de RAD51 humano con una IC50 de 27,4 μM.
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Cas No.: 1290541-46-6
Sample solution is provided at 25 µL, 10mM.
RAD51 Inhibitor B02 (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 uM.
RAD51 Inhibitor B02 specifically inhibits human RAD51 (IC50=27.4 uM), but not its E. coli homologue RecA (IC50>250 uM)[1]. The combination of B02 with cisplatin has the strongest killing effect on the human breast cancer cells MDA-MB-231[2].
B02 significantly enhances the therapeutic effect of cisplatin on tumor cells in vivo. B02 is tolerated by mice at doses up to 50 mg/kg without obvious body weight loss. No inhibition of tumor growth is observed on mice solely treated by B02. Mice treated with 4 mg/kg cisplatin, however, shows a 33% inhibition of tumor growth. Finally, mice treated with 50 mg/kg B02 and 4 mg/kg cisplatin shows a 66% inhibition of tumor growth[2].
References:
[1]. Huang F, et al. Identification of specific inhibitors of human RAD51 recombinase using high-throughput screening. ACS Chem Biol. 2011 Jun 17;6(6):628-35.
[2]. Huang F, et al. A small molecule inhibitor of human RAD51 potentiates breast cancer cell killing by therapeutic agents in mouse xenografts. PLoS One. 2014 Jun 27;9(6):e100993.
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