(S)-IDO1-IN-5 |
| Catalog No.GC38878 |
(S)-IDO1-IN-5 (Ejemplo 1B) es un S-isÓmero activo de IDO1-IN-5. (S)-IDO1-IN-5 se une a IDOL con un valor IC50 inferior a 1,5 μμ. IDO1-IN-5 es un inhibidor potente, selectivo y penetrado en el cerebro de la actividad de la indoleamina 2,3-dioxigenasa 1 (IDO1), se une a apo-IDO1 que carece de hemo en lugar de IDO1 unido a hemo maduro.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2166616-76-6
Sample solution is provided at 25 µL, 10mM.
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(S)-IDO1-IN-5 is the S-isomer of IDO1-IN-5. IDO1-IN-5 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1[1].
[1]. Frank C. Dorsey, et al. Abstract 5245: Identification and characterization of the IDO1 inhibitor LY3381916. Cancer Research. 2018, 78(13).
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