SJF 1528 |
| Catalog No.GC50748 |
Degrador potente de EGFR (los valores DC50 son 39
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2230821-38-0
Sample solution is provided at 25 µL, 10mM.
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Potent EGFR Degrader (DC50 values are 39.2 nM for wild-type EGFR in OVCAR8 cells and 736 nM for Exon20Ins mutated EGFR in HeLa cells). Also degrades HER2. Comprises the EGFR inhibitor lapatinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Inhibits proliferation of HER2-driven breast cancer cell lines (IC50 = 102 nM for SKBr3 cells).
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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