SPT Imidazopyridine 1 |
| Catalog No.GC50328 |
SPT La imidazopiridina 1 (compuesto 1) es un potente inhibidor de SPT (serina palmitoil transferasa) activo por vÍa oral, con una IC50 de 5,19 nM para hSPT1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1933533-18-6
Sample solution is provided at 25 µL, 10mM.
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Potent serine palmitoyl transferase (SPT) inhibitor (IC50 = 5 nM). Dose-dependently inhibits incorporation of 14C-serine into ceramide. Reduces plasma ceramide levels in vivo. Also increases plasma HDL and reduces vLDL cholesterol levels in rats.
Genin et al (2016) Imidazopyridine and pyrazolopiperidine derivatives as novel inhibitors of serine palmitoyl transferase. J.Med.Chem. 59 5904 PMID:27213958
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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