Targapremir-210 (Synonyms: TGP-210) |
| Catalog No.GC32435 |
Targapremir-210 (TGP-210) es un inhibidor potente y selectivo de miR-210 (miRNA-210, microRNA-210). Targapremir-210 inhibe el procesamiento pre-miR-210 con alta afinidad de uniÓn (Kd~200 nM).
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Cas No.: 1049722-30-6
Sample solution is provided at 25 µL, 10mM.
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Targapremir-210 is a potent miR-210 inhibitor with an IC50 of 200 nM in MDA-MB-231 cells. Targapremir-210 binds to the Dicer site of the miR-210 hairpin precursor. This interaction inhibits production of the mature miRNA.
[1]. Costales MG, et al. Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit. J Am Chem Soc. 2017 Mar 8; 139(9):3446-3455.
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