TC JL 37 |
| Catalog No.GC50350 |
TC JL 37 es un inhibidor de TYK2 potente, selectivo y biodisponible por vía oral con una Ki de 1,6 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1258294-34-6
Sample solution is provided at 25 µL, 10mM.
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Potent inhibitor of tyrosine kinase 2 (TYK2, Ki = 1.6 nM). Shows some selectivity for TYK2 over JAK1/2/3. Inhibits IFNγ production in vivo in mice. Orally bioavailable.
Liang et al (2013) Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors. J.Med.Chem. 56 4521 PMID:23668484
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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