Tradipitant (VLY-686) (Synonyms: VLY-686; LY686017) |
Catalog No.GC33735 |
Tradipitant (VLY-686) (VLY-686) es un antagonista de la neuroquinina-1 (NK-1).
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Cas No.: 622370-35-8
Sample solution is provided at 25 µL, 10mM.
Tradipitant is a neurokinin-1 (NK-1) antagonist.
Results reveal that Tradipitant ([3H]-LY686017) bind to sections of guinea pig brain with a distribution similar to that previously reported for NK-1 receptors. Areas with the highest density are the accessory olfactory nucleus, anteroventral thalamic nucleus, paraventricular hypothalamic nucleus central amygdaloid nucleus (lateral) and the medial amygdaloid nucleus (anterodorsal)[1].
Autoradiography experiments reveal that intravenously administered Tradipitant ([3H]-LY686017) localizes in the guinea pig brain and has a distribution similar to that described for the NK-1 receptor using agonist or antagonist radioligands[1].
[1]. Gackenheimer SL, et al. In vitro and ex vivo autoradiography of the NK-1 antagonist [³H]-LY686017 in Guinea pig brain. Neuropeptides. 2011 Apr;45(2):157-64.
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