Ro 31-9790 (GI4747) (Synonyms: GI4747) |
Catalog No.GC33881 |
Ro 31-9790 (GI4747) es un inhibidor sintético de metaloproteinasas (MMP).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 145337-55-9
Sample solution is provided at 25 µL, 10mM.
Ro 31-9790 is a synthetic metalloproteinase (MMP) inhibitor.
Ro 31-9790 inhibits L-selectin shedding from mouse and human lymphocytes, Jurkat T cells, and human monocytes with an IC50 of 0.3-0.4 μM on these cell types. The IC50 values obtained for Ro 31-9790 are 4.82 ± 0.75 μM, 1.16 ± 0.27 μM, 0.70 ± 0.06 μM, 4.47± 1.27 μM and 0.38 ± 0.05 μM for mouse lymphocyte L-selectin shedding, Jurkat L-selectin shedding, human lymphocyte L-selectin shedding, human monocyte L-selectin shedding and human monocyte TNF-α shedding[1].
[1]. Borland G, et al. Tissue inhibitor of metalloproteinases-3 inhibits shedding of L-selectin from leukocytes. J Biol Chem. 1999 Jan 29;274(5):2810-5.
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