rTRD01 |
| Catalog No.GC71276 |
rTRD01 es un ligando TDP-43 que se une a los dominios RRM1 y RRM2 de TDP-43 (Kd=89 uM para TDP-43102-269).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1332175-56-0
Sample solution is provided at 25 µL, 10mM.
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rTRD01 is a TDP-43 ligand that binds to TDP-43’s RRM1 and RRM2 domains (Kd=89 uM for TDP-43102–269). rTRD01 partially disrupts TDP-43’s interaction with the hexanucleotide RNA repeat of the disease-linked c9orf72 gene. rTRD01 can be used for the research of neurodegenerative diseases.
References:
[1]. François-Moutal L, et al. Small Molecule Targeting TDP-43's RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS). ACS Chem Biol. 2019 Sep 20;14(9):2006-2013.
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