SB-209670 |
| Catalog No.GC71536 |
SB-209670 es un extremadamente potente y altamente específico no péptido, subnanomolar endotelina (ET) antagonista del receptor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 157659-79-5
Sample solution is provided at 25 µL, 10mM.
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SB-209670 is an extremely potent and highly specific non-peptide, subnanomolar endothelin (ET) receptor antagonist. SB 209670 selectively inhibits binding of 125I-labeled ET-1 to cloned human ET receptor subtypes ETA and ETB (Ki=0.2 and 18 nM, respectively). SB 209670 produces a dose-dependent reduction in blood pressure in hypertensive rats, protects from ischemia-induced neuronal degeneration in a gerbil stroke model, and attenuates neointima formation following rat carotid artery balloon angioplasty.
References:
[1]. E H Ohlstein, et al. SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist. Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8052-6.
Review for SB-209670
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
Review for SB-209670
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