SCH 32615 |
| Catalog No.GC61457 |
SCH 32615 es un inhibidor de la encefalinasa (las enzimas responsables de la degradaciÓn de las encefalinas endÓgenas).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 83861-02-3
Sample solution is provided at 25 µL, 10mM.
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SCH 32615 is an enkephalinase (the enzymes responsible for the degradation of endogenous enkephalins) inhibitor. SCH 32615 can enhance surgery- and pregnancy-induced analgesia in mice[1][2].
SCH 32615 blocks the degradation of Met5-enkephalin by isolated enkephalinase, with the Ki of 19.5 nM[3].
SCH 32615 (150 mg/kg; s.c.) enhances surgery activated endogenous analgesia in mice[1].
[1]. Jayaram A, et, al. An enkephalinase inhibitor, SCH 32615, augments analgesia induced by surgery in mice. Anesthesiology. 1995 May;82(5):1283-7. [2]. Jayaram A, et, al. SCH 32615, an enkephalinase inhibitor, enhances pregnancy-induced analgesia in mice. Anesth Analg. 1995 May;80(5):944-8. [3]. Chipkin RE, et, al. Pharmacology of SCH 34826, an orally active enkephalinase inhibitor analgesic. J Pharmacol Exp Ther. 1988 Jun;245(3):829-38.
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