SJ10542 |
| Catalog No.GC64464 |
SJ10542 es un potente y selectivo JAK2/3 que dirige fenil glutarimida (PG)-PROTAC con DC50 de 14, 11 y 24 nM para JAK2, JAK3 y JAK2-fusion ALL, respectivamente.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2789678-92-6
Sample solution is provided at 25 µL, 10mM.
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SJ10542 is a potent and selective JAK2/3 directing phenyl glutarimide (PG)-PROTAC with DC50s of 14, 11, and 24 nM for JAK2, JAK3, and JAK2-fusion ALL, respectively. SJ10542 utilizes a PG ligand as the cereblon (CRBN) recruiter[1].
[1]. Lisa J.Alcock,et al. Development of Potent and Selective Janus Kinase 2/3 Directing PG-PROTACs.ACS Med.Chem.Lett.2022,13,3,475-482.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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