SLC26A3-IN-2 |
| Catalog No.GC71079 |
SLC26A3-IN-2 es un inhibidor activo oral de la proteína de intercambio de aniones SLC26A3 (IC50=360 nM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 950348-60-4
Sample solution is provided at 25 µL, 10mM.
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SLC26A3-IN-2 (compound 3a) (10 μM; 10 min) produces 92% inhibition rate against SLC26A3[1].
SLC26A3-IN-2 (10 mg/kg; po) significantly increases stool weight and number of pellets in a Loperamide -induced model of constipation in mice, demonstrating its efficacy in increasing stool hydration in mice[1].
References:
[1]. Cil O, et al. Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action. Eur J Med Chem. 2023 Mar 5;249:115149.
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