SM-433 hydrochloride |
| Catalog No.GC63709 |
El clorhidrato de SM-433, un mimético de Smac, funciona como inhibidor de las proteÍnas inhibidoras de la apoptosis (IAP). El clorhidrato de SM-433 exhibe una fuerte afinidad de uniÓn a la proteÍna XIAP BIR3 con una IC50<1 μM (patente WO2008128171A2).
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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SM-433 hydrochlorid, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 hydrochlorid exhibits strong binding affinity XIAP BIR3 protein with an IC50<1 μM (patent WO2008128171A2)[1].
SM-433 hydrochlorid exhibits strong inhibitory activity against MDA-MB -2131 human breast cancer cells and SK-OV-3 ovarian cancer cells (IC50s<10 μM, respectively)[1].
[1]. Shaomeng Wang, et al. Diazo bicyclic smac mimetics and the uses thereof. WO2008128171A2.
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