Stilbamidine dihydrochloride |
| Catalog No.GC72480 |
La diclorodifenilamina es un compuesto de difenilamina derivado del estilbeno y se utiliza principalmente en forma de su isotianato cristalino para tratar diversas infecciones fúngicas.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 6935-63-3
Sample solution is provided at 25 µL, 10mM.
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The high-affinity pentamidine transporter (HAPT1) is inhibited by Propamidine but displays only low affinity to Stilbamidine dihydrochloride. adenosine-sensitive pentamidine transporter (ASPT1), in contrast, is strongly inhibited by Stilbamidine dihydrochloride, and Propamidine. [3H]pentamidine uptake is determined in the presence of various concentrations of adenosine (IC50=1.2 μM) or melarsen oxide (IC50=0.7 μM), as well as in the presence of 250 μM adenosine and increasing concentrations of hypoxanthine, Propamidine (IC50=6.1 μM) and Stilbamidine dihydrochloride (IC50=110 μM)[1]. The two diamidine compounds, Stilbamidine dihydrochloride and Pentamidine are used to treat in multiple myeloma, a disease in which increase of the globulin content of the serum is of frequent occurrence[2].
References:
[1]. De Koning HP. Uptake of pentamidine in Trypanosoma brucei brucei is mediated by three distinct transporters: implications for cross-resistance with arsenicals. Mol Pharmacol. 2001 Mar;59(3):586-92.
[2]. BREWER AE.et al. Multiple myeloma treated with stilbamidine and pentamidine. Br Med J. 1948 Dec 4;2(4587):978-82.
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