TC-E 5008 |
| Catalog No.GC50129 |
Selective mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor; phenotypically lethal
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Cas No.: 50405-58-8
Sample solution is provided at 25 µL, 10mM.
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Selective mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor (Ki = 120-190 nM). Displays >60-fold selectivity for mIDH1 (found in ~75% of gliomas) over wild type IDH1. Also inhibits D-2-hydroxyglutaric acid in cells expressing mIDH1 (EC50 = 2.4 μM). Does not display cytotoxicity towards non-cancerous human cells. Phenotypically lethal.
Zheng et al (2013) Crystallographic investigation and selective inhibition of mutant isocitrate dehydrogenase. ACS Med.Chem.Lett. 4 542 PMID:23795241
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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