TC-G 1005 |
Catalog No.GC50107 |
TC-G 1005 es un agonista potente, selectivo y activo por vÍa oral del receptor 5 acoplado a proteÍna Takeda G del receptor BA (TGR5), con CE50 de 0,72 y 6,2 nM para hTGR5 y mTGR5, respectivamente.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1415407-60-1
Sample solution is provided at 25 µL, 10mM.
Potent and selective GPBA agonist (EC50 = 0.72 nM for hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and reduces blood glucose in mice. Orally available.
Duan et al (2012) Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists. J.Med.Chem. 55 10475 PMID:23148522
Average Rating: 5
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