TPh A |
Catalog No.GC61815 |
TPh A (Trifenil Compuesto A) es un potente inhibidor de la proteÍna nuclear pirina y se une especÍficamente a la pirina con una Ki de 0,6 uM. TPh A interrumpe la formaciÓn del complejo bcl3-pirina. TPh A se puede utilizar como una nueva herramienta de molécula pequeÑa para regular la pirina en las células.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 21306-65-0
Sample solution is provided at 25 µL, 10mM.
TPh A (Triphenyl Compound A) is a potent inhibitor of the nuclear protein pirin and binds specifically to pirin with a Ki of 0.6 uM. TPh A disrupts the formation of the bcl3-pirin complex. TPh A can be used as a novel small molecule tool to regulate pirin in cells[1].
The Pirin is a nuclear protein with the nuclear factor I/CCAAT box transcription factor (NFI/CTF). Pirin proteins are highly conserved between mammals, plants, fungi, and prokaryotic organisms and are considered to belong to the cupin superfamily.TPh A (20 µM; 5 hours) reduces the amount of pirin-bound Bcl3 and inhibits the interaction between pirin and Bcl3 in HEK293T cells in a glutathione S-transferase (GST) pulldown assay (HEK293T cells are transfected with vectors that encoded bcl3-Myc and pirin-His6 for 43 h of transfection)[1].TPh A (0-100 µM; 48 hours) does not exert any potent cytotoxic activity against many human cancer cell lines, it against MCF7, MDA-MB231, HeLa, DU145, HepG2, A549, HT1080, WM266-4, and SK-MEL-28 cells with IC50 values >50 µM, and exhibits IC50 values of 27 µM, 20 µM and 26 µM for PC3 HL60 and HT29 cells, respectively[1].TPhA (0-50 µM; 48 hours) inhibits cell migration in WM266-4 cells, SK-MEL-28 cell in a concentration-dependent manner[1].
References:
[1]. Isao Miyazaki, et al. A Small-Molecule Inhibitor Shows That Pirin Regulates Migration of Melanoma Cells. Nat Chem Biol. 2010 Sep;6(9):667-73.
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