UCB-5307 |
| Catalog No.GC66460 |
UCB-5307 es un potente inhibidor de la seÑalizaciÓn de TNF con una KD de 9 nM para TNFα humano. UCB-5307 puede penetrar el complejo hTNF/hTNFR1 preformado.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1515887-44-1
Sample solution is provided at 25 µL, 10mM.
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UCB-5307 is a potent TNF signaling inhibitor with a KD of 9 nM for human TNFα. UCB-5307 can penetrate the preformed hTNF/hTNFR1 complex[1].
UCB-5307 inhibits wild-type TNF but does not inhibit L57F TNF. The T1/2 of UCB-5307 is 3.3 h[1].
UCB-5307 disrupts a preformed hTNF/hTNFR1 complex, can penetrate the preformed complex, dislodging one of the receptors. Preloading hTNF with UCB-5307 blocks one receptor from binding[1].
UCB-5307 binds to a pocket in the centre of the TNF trimer formed by the movement of the TNF monomers, stabilising the distorted trimer, which leads to reduced signalling through TNFR1[1].
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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