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Urotensin I (Catostomus urotensin I)

Catalog No.GC32590

La urotensina I (Catostomus urotensina I) (Catostomus urotensina I), un neuropéptido similar a CRF, actÚa como un agonista del receptor de CRF con pEC50 de 11,46, 9,36 y 9,85 para CRF1 humano, CRF2 humano y CRF2α de rata; receptores en células CHO y Kis de 0,4, 1,8 y 5,7 nM para hCRF1, rCRF2α y mCRF2β receptores, respectivamente.

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Urotensin I (Catostomus urotensin I) Chemical Structure

Cas No.: 83930-33-0

Tamaño Precio Disponibilidad Cantidad
500μg
239,00 $
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1mg
414,00 $
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5mg
1.241,00 $
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Sample solution is provided at 25 µL, 10mM.

Description of Urotensin I (Catostomus urotensin I)

Urotensin I is, 41-aa neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors, respectively.

Urotensin I is a 41-aa neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells[1] and with Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors in cell assay, respectively[2]. Urotensin I exhibits a striking sequence homology with ovine corticotropin-releasing factor and with frog sauvagine, and has potent hypotensive activity and corticotropin-releasing activity[3]. Urotensin I stimulates the release of ACTH from an isolated dispersed goldfish anterior pituitary cell column[4].

[1]. Smart D, et al. Characterisation using microphysiometry of CRF receptor pharmacology. Eur J Pharmacol. 1999 Aug 27;379(2-3):229-35. [2]. Reul JM, et al. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol. 2002 Feb;2(1):23-33. [3]. Lederis K, et al. Complete amino acid sequence of urotensin I, a hypotensive and corticotropin-releasing neuropeptide from Catostomus. Science. 1982 Oct 8;218(4568):162-5. [4]. Fryer J, et al. Urotensin I, a CRF-like neuropeptide, stimulates acth release from the teleost pituitary. Endocrinology. 1983 Dec;113(6):2308-10.

Chemical Properties of Urotensin I (Catostomus urotensin I)

Cas No. 83930-33-0 SDF
Canonical SMILES Asn-Asp-Asp-Pro-Pro-Ile-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Asn-Met-Ile-Glu-Met-Ala-Arg-Ile-Glu-Asn-Glu-Arg-Glu-Gln-Ala-Gly-Leu-Asn-Arg-Lys-Tyr-Leu-Asp-Glu-Val-NH2
Formula C210H340N62O67S2 M.Wt 4869.46
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Urotensin I (Catostomus urotensin I)

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1 mg 5 mg 10 mg
1 mM 0.2054 mL 1.0268 mL 2.0536 mL
5 mM 0.0411 mL 0.2054 mL 0.4107 mL
10 mM 0.0205 mL 0.1027 mL 0.2054 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 5 reference(s) in Google Scholar.)

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