WEE1-IN-5 |
| Catalog No.GC65994 |
WEE1-IN-5 es un potente inhibidor de WEE1 con un valor IC50 de 0,8 nM. WEE1-IN-5 inhibe fosfo-CDC2. WEE1-IN-5 anula el punto de control G2, aumentando la sensibilidad a los agentes que daÑan el ADN en las células cancerosas. WEE1-IN-5 se puede utilizar para investigar el cÁncer.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2243882-74-6
Sample solution is provided at 25 µL, 10mM.
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WEE1-IN-5 is a potent WEE1 inhibitor with an IC50 value of 0.8 nM. WEE1-IN-5 inhibits phospho-CDC2. WEE1-IN-5 abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. WEE1-IN-5 can be used for researching anticancer[1].
WEE1-IN-5 exhibits an EC50 of 188 nM in pCDC2 and an IC50 shift for CYP3A4/5[1].
WEE1-IN-5 (5mg/kg for PO; 1 mg/kg for IV; single dosage) exhibits a CL of 14 mL/min/kg, an AUCint 1324 h.ng/mL and bioavailability of 35% in SD rats[1].
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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