Wee1 Inhibitor |
Catalog No.GC49430 |
Wee1 Inhibitor es un potente inhibidor de la quinasa Wee1 del punto de control con un IC50 de 0,011 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 622855-37-2
Sample solution is provided at 25 µL, 10mM.
Wee1 inhibitor is an inhibitor of the checkpoint kinase Wee1 (IC50 = 11 nM).1 It is selective for Wee1 over checkpoint kinase 1 (Chk1; IC50 = 440 nM). Wee1 inhibitor also inhibits the ATPase activity of LptB, an enzyme involved in the transport and assembly of LPS (IC50 = 25 µM for the E. coli enzyme).2
1.Palmer, B.D., Thompson, A.M., Booth, R.J., et al.4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitutionJ. Med. Chem.49(16)4896-4911(2006) 2.Gronenberg, L.S., and Kahne, D.Development of an activity assay for discovery of inhibitors of lipopolysaccharide transportJ. Am. Chem. Soc.132(8)2518-2519(2010)
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(Based on Reviews and 29 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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