Win-62005 |
| Catalog No.GC32659 |
Win-62005 es un inhibidor de la fosfodiesterasa III (PDE III) de AMP cÍclico con Kis de 25 y 26 nM para corazÓn de rata y aorta canina, respectivamente.
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Cas No.: 152633-54-0
Sample solution is provided at 25 µL, 10mM.
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Win-62005 is a cyclic AMP phosphodiesterase III (PDE III) inhibitor with Kis of 25 and 26 nM for rat heart and canine aorta, respectively.
Win-62005 competitively inhibits cyclic GMP-inhibitable low Km cyclic AMP phosphodiesterase (PDE III) from rat heart and canine aorta with Ki values of 25±3 and 26±5 nM, respectively and is selective (at least 160-fold) for PDE III inhibition relative to other PDE isozymes[1].
After p.o. administration of 1 mg/kg Win-62005, LVdP/dtmax is significantly increased in 30 min and remains increased for at least 6 h[1].
[1]. Dundore RL, et al. Species-dependent pharmacodynamic effects of the selective low Km cyclic AMP phosphodiesterase III inhibitors WIN 58993 and WIN 62005. J Cardiovasc Pharmacol. 1995 Jan;25(1):14-21.
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