Zilovertamab (Synonyms: UC-961; Cirmtuzumab) |
| Catalog No.GC66327 |
Zilovertamab (UC-961) es un anticuerpo monoclonal humanizado contra ROR1 que bloquea la seÑalizaciÓn de ROR1 inducida por Wnt5a.
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Sample solution is provided at 25 µL, 10mM.
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Zilovertamab (UC-961) is a humanised monoclonal antibody against ROR1 that blocks Wnt5a-induced ROR1 signalling[1].
Zilovertamab (25 and 50 µg/mL; 72 h) inhibits high-grade serous ovarian cancer (HGSOC) cell proliferation[1].
Zilovertamab (50 µg/mL; 72 h) down-regulates ROR1 expression levels in CaOV3 at the transcriptional level[1].
Cell Proliferation Assay[1]
| Cell Line: | CaOV3, CaOV3CisR, PEO1, and PEO4 cells |
| Concentration: | 25 and 50 µg/mL |
| Incubation Time: | 72 hours |
| Result: | Reduced the proliferation of CaOV3, CaOV3CisR and PEO1. |
Western Blot Analysis[1]
| Cell Line: | CaOV3, CaOV3CisR, PEO1, and PEO4 cells |
| Concentration: | 50 µg/mL |
| Incubation Time: | 72 hours |
| Result: | Down-regulated ROR1 expression levels in CaOV3 at the transcriptional level. |
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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