SPDB |
Catalog No.GC30150 |
SPDB is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 115088-06-7
Sample solution is provided at 25 µL, 10mM.
SPDB is a small fragment that can linked DM4 conjugates. Conjugated to antibodies utilizing disulfide linkers: anti-EGFR-SPDB-DM4 has been widely used.
[1]. Widdison WC et al. Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolitesin Cancer Cells andInduce High Levels of Bystander Killing. Bioconjug Chem, 2015 Nov 18, 26(11):2261-78.
Average Rating: 5
(Based on Reviews and 25 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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