Spironolactone-d3 |
| Catalog No.GC91414 |
Spironolactone-d3 is intended for use as an internal standard for the quantification of spironolactone by GC- or LC-MS.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Spironolactone-d3 is intended for use as an internal standard for the quantification of spironolactone by GC- or LC-MS. Spironolactone is a steroidal mineralocorticoid receptor antagonist (IC50 = 24 nM) and a diuretic.1 It is selective for the mineralocorticoid receptor over the glucocorticoid receptor (IC50 = 2,410 nM) but also binds to the androgen receptor and progesterone receptor (IC50s = 77 and 743 nM, respectively). In vivo, spironolactone (37.5 mg/kg per day) administered in combination with lisinopril preserves ejection fraction in mice and reduces myocardial fibrosis in a mouse model of Duchenne muscular dystrophy (DMD).2 Formulations containing spironolactone have been used in the treatment of hypertension and heart failure.
Review for Spironolactone-d3
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
Review for Spironolactone-d3
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