Sulprostone |
| Catalog No.GC17861 |
EP3 and EP1 receptor agonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 60325-46-4
Sample solution is provided at 25 µL, 10mM.
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Sulprostone is a metabolism resistant synthetic analog of PGE2.[1] It is a selective agonist for EP3 receptors with a Ki value of 0.35 nM at the human recombinant EP3-III receptor and an IC50 of 0.01 µM for the inhibition of PGE2 binding.[2],[3] Sulprostone is a potent stimulator of uterine smooth muscle contractions with high abortifacient activity.[4],[5]
Reference:
[1]. Schaaf, T.K., Bindra, J.S., Eggler, J.F., et al. N-(methanesulfonyl)-16-phenoxyprostaglandincarboxamides: Tissue-selective, uterine stimulants. Journal of Medicinal Chemistry 24, 1353-1359 (1981).
[2]. Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochimica et Biophysica Acta 1483, 285-293 (2000).
[3]. Negishi, M., Harazono, A., Sugimoto, Y., et al. TEI-3356, a highly selective agonist for the prostaglandin EP3 receptor. Prostaglandins 48, 275-283 (1994).
[4]. Schillinger, E., Prior, G., Speckenbach, A., et al. Receptor binding in various tissues of PGE2, and sulprostone, a novel PGE2-derivative. Prostaglandins 18, 293-302 (1979).
[5]. Krishna, U., Gupta, A.N., Ma, H.K., et al. Randomized comparison of different prostaglandin analogues and laminaria tent for preoperative cervical dilation. Contraception 34, 237-251 (1986).
| Cas No. | 60325-46-4 | SDF | |
| Chemical Name | (Z)-7-((1R,2R,3R)-3-hydroxy-2-((R,E)-3-hydroxy-4-phenoxybut-1-en-1-yl)-5-oxocyclopentyl)-N-(methylsulfonyl)hept-5-enamide | ||
| Canonical SMILES | O[C@H](C1)[C@H](/C=C/[C@H](COC2=CC=CC=C2)O)[C@@H](C/C=C\CCCC(NS(=O)(C)=O)=O)C1=O | ||
| Formula | C23H31NO7S | M.Wt | 465.56 |
| Solubility | DMF: >10 mg/ml,DMSO: >14 mg/ml,Ethanol: >25 mg/ml,PBS pH 7.2: >4 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.148 mL | 10.7398 mL | 21.4795 mL |
| 5 mM | 0.4296 mL | 2.148 mL | 4.2959 mL |
| 10 mM | 0.2148 mL | 1.074 mL | 2.148 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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