Taurodeoxycholic Acid (sodium salt) |
Catalog No.GC44995 |
Taurodeoxycholic Acid (sodium salt) is a bile salt-related anionic detergent used for isolation of membrane proteins including inner mitochondrial membrane proteins.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1180-95-6
Sample solution is provided at 25 µL, 10mM.
Taurodeoxycholic acid (TDCA) is one of the Bile salts, are normally found within the intestinal lumen. The primary function of bile salts is to aid in the absorption of lipids and lipid-soluble vitamins. However, recent studies have shown that bile salts have other biologic effects independent of their role in digestion[1].
Several effects of bile acids (BAs) on colonic epithelial cells (CECs) have been described, including induction of proliferation and apoptosis. Taurodeoxycholic acid (TDCA) is capable of inducing classic NF-κB activation in hepatoma cells, and induced IL-8 expression in a dose- and time-dependent manner. that there seems to be a classical NF-κB-dependent and an independent pathway in BA-induced IL-8 expression in CECs[2].
The bile salt taurodeoxycholic acid (TDCA) has been associated with increased growth of esophageal mucosa in a rabbit explant model. Taurodeoxycholic acid increased gallbladder eicosanoid release in a dose-related manner with 6-keto-PGF1 alpha and PGE2 release 10-fold higher than TXB2.These findings suggest that the increased release of gallbladder PGI2 and PGE2 described in animal models of cholecystitis may, in part, be related to increased gallbladder bile levels of taurodeoxycholic acid[3].
References:
[1].Perrone EE, Chen C, et al. Warner BW, Sun CC, Alaish SM, Strauch ED. Dietary bile acid supplementation improves intestinal integrity and survival in a murine model. J Pediatr Surg. 2010 Jun;45(6):1256-65.
[2]. Mühlbauer M, Allard B, et al. Differential effects of deoxycholic acid and taurodeoxycholic acid on NF-kappa B signal transduction and IL-8 gene expression in colonic epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2004 Jun;286(6):G1000-8.
[3]. Myers SI, Riva A, et al. Taurodeoxycholic acid stimulates rabbit gallbladder eicosanoid release. Prostaglandins Leukot Essent Fatty Acids. 1995 Jan;52(1):35-9.
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