Temozolomide Acid (Synonyms: Temozolomide 8-Carboxylic Acid, TMZA) |
| Catalog No.GC52076 |
Temozolomide Acid is a carboxylic acid derivative of Temozolomide. Temozolomide is a DNA alkylating agent, methylating the guanine and adenine bases of DNA, causing breaks in DNA double strand, cell cycle arrest, and eventually cell death. Temozolomide Acid has an activity similar to the parent compound Temozolomide with the same anticancer activity.
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Cas No.: 113942-30-6
Sample solution is provided at 25 µL, 10mM.
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Temozolomide acid is an active metabolite of the alkylating agent precursor temozolomide .1 It is cytotoxic to TLX5 murine lymphoma cells in a concentration-dependent manner. Temozolomide acid is also a synthetic intermediate in the synthesis of temozolomide prodrugs with anticancer activity.2
1.Tsang, L.L.H., Farmer, P.B., Gescher, A., et al.Characterisation of urinary metabolites of temozolomide in humans and mice and evaluation of their cytotoxicityCancer Chemother. Pharmacol.26(6)429-436(1990) 2.Liu, D., Yang, J.-G., Cheng, J., et al.Synthesis and antitumor activity of 3-methyl-4-oxo-3,4-dihydroimidazo [5,1-d][1,2,3,5]tetrazine-8-carboxylates and -carboxamidesMolecules15(12)9427-9437(2010)
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