Triciribine Phosphate |
| Catalog No.GC90702 |
An Akt activation inhibitor and active metabolite of triciribine
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 61966-08-3
Sample solution is provided at 25 µL, 10mM.
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Triciribine phosphate is an Akt activation inhibitor and an active metabolite of the prodrug triciribine .1,2 Upon entry into cells, triciribine is metabolized to triciribine phosphate by adenosine kinase (AK).2 It binds to the Pleckstrin homology (PH) domain of Akt and prevents its recruitment to the plasma membrane in MDA-MB-468 cells.1 Triciribine phosphate reduces the proliferation of A1847 and A2780 ovarian cancer cells (IC50s = 1.6 and 18 µM, respectively).3 It inhibits HIV-1 reverse transcriptase activity in CEM-SS cells (IC50 = 0.04 µM), as well as herpes simplex virus 1 (HSV-1) replication in BS-C-1 cells and human cytomegalovirus (CMV) plaque formation in HFF-1 IRR cells (IC50s = 20 and 0.8 µM, respectively).4
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