Vinclozolin M2 (Synonyms: M2) |
| Catalog No.GC48252 |
Antagonist of the androgen receptor in rats
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 83792-61-4
Sample solution is provided at 25 µL, 10mM.
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Vinclozolin is a dicarboximide fungicide widely used in Europe and the United States for control of diseases caused by B. cinerea, S. sclerotiorum, and Monilinia species in grapes, fruits, vegetables, ornamental plants, and turfgrass.1 Metabolites of vinclozolin, M1 and M2, are effective antagonists of the androgen receptor in rats exhibiting Ki values of 92 and 9.7 µM respectively.2 In fathead minnow, M1 and M2 failed to compete for high-
1.Pothuluri, J.V., Freeman, J.P., Heinze, T.M., et al.Biotransformation of vinclozolin by the fungus Cunninghemella elegansJ. Agric. Food Chem.48(12)6138-6148(2000) 2.Kelce, W.R., Monosson, E., Gamcsik, M.P., et al.Enviromental hormone disruptors: Evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolitesToxicol. Appl. Pharmacol.126(2)276-285(1994) 3.Makynen, E.A., Kahl, M.D., Jensen, K.M., et al.Effects of the mammalian antiandrogen vinclozolin on development and reproduction of the fathead minnowAquatic Toxicology48461-475(2000)
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