VU6010572 |
| Catalog No.GC70527 |
VU6010572 is a potent and selective mGlu3 negative allosteric modulator with IC50 of 245 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2126784-39-0
Sample solution is provided at 25 µL, 10mM.
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VU6010572 (3 mg/kg; i.p.) shows robust efficacy[1].
VU6010572 (3 mg/kg; i.p.; 45 minutes) produces lasting anxiolytic-like behavioral effects[2].
References:
[1]. Engers JL, et al. Design and Synthesis of N-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs. ACS Med Chem Lett. 2017;8(9):925-930. Published 2017 Aug 15.
[2]. Ryan E. Tyler1, et al. The effects of predator odor (TMT) exposure and mGlu3 NAM pretreatment on lasting behavioral and molecular adaptations in the insular cortex and BNST
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