WCK-4234 |
| Catalog No.GC64544 |
WCK-4234 is a potent β-lactamase inhibitor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1804915-68-1
Sample solution is provided at 25 µL, 10mM.
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WCK-4234 is a potent β-lactamase inhibitor. WCK-4234 inhibits class A, C, and D β-lactamases activity. WCK-4234 lacks direct antibacterial activity. WCK-4234 potentiates imipenem and meropenem against Enterobacteriaceae with OXA-48/OXA-181 or KPC enzymes, or with combinations of impermeability and AmpC or ESBL activity. WCK-4234 distinctively overcomes resistance mediated by OXA-type carbapenemases[1][2].
[1]. Iregui A, et al. Activity of Meropenem with a Novel Broader-Spectrum β-Lactamase Inhibitor, WCK 4234, against Gram-Negative Pathogens Endemic to New York City. Antimicrob Agents Chemother. 2019 Dec 20;64(1):e01666-19.
[2]. Mushtaq S, et al. WCK 4234, a novel diazabicyclooctane potentiating carbapenems against Enterobacteriaceae, Pseudomonas and Acinetobacter with class A, C and D β-lactamases. J Antimicrob Chemother. 2017 Jun 1;72(6):1688-1695.
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