Zilpaterol (Synonyms: RU-42173,Zilmax®) |
| Catalog No.GC13333 |
β-adrenergic receptor agonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 119520-05-7
Sample solution is provided at 25 µL, 10mM.
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Zilpaterol is a β-adrenergic receptor agonist.
β-adrenergic receptors, prototypic G-protein-coupled receptors, play a key role in regulating numerous physiological processes.
In vitro: Previus study found that there was no effect of zilpaterol (ZH) on thymidine incorporation into DNA. ZH at 1 μM could decrease β1-AR mRNA, and 0.01 and 1 μM ZH decreased β2-AR and β3-AR mRNA in myoblasts. There was no effect of ZH on the β-AR or IGF-I gene expression in fused myotube cultures. The β2-AR antagonist ICI-118, 551 attenuated the effect of ZH to reduce expression of β1- and β2-AR mRNA. There was no effect of ICI-118, 551 or ZH on β3-AR or IGF-I. In addition, the total lipid synthesis from acetate was increased by ZH in bovine subcutaneous adipose tissue explants in the absence of theophylline [1].
In vivo: FDA has approved label claims of increased rate of BW gain, improved feed efficiency, and increased carcass leanness. The feeding of ZH for 20 to 40 d with a 3-d withdrawal resulted in significantly increased ADG. Such increases equate to an average of 9 kg heavier BW in ZH-fed steers. Moreover, hot carcass weight has been shown to increase to a larger degree compared with BW, with an average improvement of 15 kg [2].
Clinical trial: So far, no clinical study has been conducted.
References:
[1] Miller, E. K.,Chung, K.Y.,Hutcheson, J.P., et al. Zilpaterol hydrochloride alters abundance of β-adrenergic receptors in bovine muscle cells but has little effect on de novo fatty acid biosynthesis in bovine subcutaneous adipose tissue explants. Journal of Animal Science 90(4), 1317-1327 (2012).
[2] Delmore, R. J.,Hodgen, J.M. and Johnson, B.J. Perspectives on the application of zilpaterol hydrochloride in the United States beef industry. Journal of Animal Science 88(8), 2825-2828 (2010).
| Cas No. | 119520-05-7 | SDF | |
| Synonyms | RU-42173,Zilmax® | ||
| Chemical Name | (6R,7R)-rel-4,5,6,7-tetrahydro-7-hydroxy-6-[(1-methylethyl)amino]-imidazo[4,5,1-jk][1]benzazepin-2(1H)-one | ||
| Canonical SMILES | O=C1NC2=CC=CC3=C2N1CC[C@H](NC(C)C)[C@H]3O | ||
| Formula | C14H19N3O2 | M.Wt | 261.3 |
| Solubility | ≤1mg/ml in DMSO;0.1mg/ml in dimethyl formamide | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.827 mL | 19.1351 mL | 38.2702 mL |
| 5 mM | 0.7654 mL | 3.827 mL | 7.654 mL |
| 10 mM | 0.3827 mL | 1.9135 mL | 3.827 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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Average Rating: 5 (Based on Reviews and 25 reference(s) in Google Scholar.)
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